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United States Department of Agriculture

Agricultural Research Service

Title: Mycobacterium Tuberculosis Infection Causes Different Levels of Apoptosis and Necrosis in Human Macrophages and Alveolar Epithelial Cells

Authors
item Danelishvili, Lin - OREGON STATE UNIVERSITY
item McGarvey, Jeffery
item Li, Yong-Jim - OREGON STATE UNIVERSITY
item Bermudez, Luiz - OREGON STATE UNIVERSITY

Submitted to: Cellular Microbiology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: June 11, 2004
Publication Date: July 20, 2003
Citation: Danelishvili, L., McGarvey, J.A., Li, Y., Bermudez, L. 2003. Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells. Cellular Microbiology. 5(9):649-660.

Interpretive Summary: Mycobacterium tuberculosis is a bacterium that causes serious disease in humans as well as livestock animals. The bacterium enters the lungs of the host and infects two types of cells. The first type cell is a blood cell that normally kills bacteria that are brought into the lungs, the second type of cell are those that line the lungs. Infection by Mycobacterium tuberculosis kills both of these cells but it is unclear how these cells die. To better understand how these cells die we infected both cell types in the laboratory and examined how they died using molecular biology techniques. The results are of interest because they advance the knowledge of how bacteria can cause disease and may lead to novel therapeutic methods.

Technical Abstract:

Last Modified: 7/25/2014
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