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ARS Home » Research » Publications at this Location » Publication #152697
Title: ESTIMATED CLEARANCE RATES FOR SIMMONDSIN METABOLITES

Author
item Holser, Ronald
item VAN BOVEN, MAURITS - KATHOLIEKE UNIV
item COKELAERE, MARNIX - KATHOLIEKE UNIV

Submitted to: Phytochemical Society of North America Meeting and Newsletter
Publication Type: Abstract Only
Publication Acceptance Date: 8/13/2003
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The jojoba plant, Simmondsia chinensis, is indigenous to the Southwest American desert and is cultivated for the wax esters in the seed. The plant also produces a group of bioactive glycosides, i. e., simmondsin, simmondsin ferulate, demethyl simmondsin, and didemethylsimmondsin, that elicits an anorexic response in mammals after ingestion. These glycosides are distributed throughout the plants tissues and may protect the plant from predation by herbivores. Simmondsin, 2-cyanomethylene-3 hydroxy 4, 5 dimethoxycyclohexyl D glycoside, has been studied in controlled feeding trials with Wistar rats. A two-compartment model was applied to dose-response data to describe the absorption of simmondsin and estimate the clearance rates of the aglycan in rats fed 5 mg simmondsin/g meal over a four-hour period.