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United States Department of Agriculture

Agricultural Research Service

Title: Use of Sodium Salt of Nitroethane to Reduce Salmonella Typhimurium in Weaned Pigs

Authors
item Jung, Yong Soo
item Anderson, Robin
item Genovese, Kenneth
item Edrington, Thomas
item Byrd, James
item Bischoff, Kenneth
item Callaway, Todd
item Mcreynolds, Jack - TX A&M UNIVERSITY
item Harvey, Roger
item Nisbet, David

Submitted to: Proceedings of Allen D Leman Swine Conference
Publication Type: Proceedings
Publication Acceptance Date: September 13, 2003
Publication Date: September 13, 2003
Citation: JUNG, Y., ANDERSON, R.C., GENOVESE, K.J., EDRINGTON, T.S., BYRD II, J.A., BISCHOFF, K.M., CALLAWAY, T.R., MCREYNOLDS, J., HARVEY, R.B., NISBET, D.J. USE OF SODIUM SALT OF NITROETHANE TO REDUCE SALMONELLA TYPHIMURIUM IN WEANED PIGS. PROCEEDINGS OF ALLEN D. LEMAN SWINE CONFERENCE. 2003. V. 30(SUPPL.). P. 27.

Technical Abstract: The objective of this study was to determine the bactericidal activity of a sodium salt of nitroethane (SNE) against Salmonella Typhimurium (ST) in the cecum and rectum of weaned pigs. Pigs were divided into four groups (n = 10/group); control (0 g NE equivalents/pig), 1 X (0.2 g NE equivalents/pig), 5 X (1 g NE equivalents/pig), and 10 X (2 g NE equivalents/pig). Sodium salt of NE was administered via oral gavage 24 h before sacrifice. Cecal and rectal contents were collected and ST populations were determined quantitatively and qualitatively. Significant (P < 0.05) reductions of ST populations (mean log10 CFU/g +/- SD) were observed following SNE treatment at 5 and 10X doses in the cecum compared to controls (3.43 +/- 1.55, 3.22 +/- 1.35 vs 5.10 +/- 1.03, respectively). Pooled data show that there was a significant treatment effect of SNE on reductions of Salmonella at 10 X dose level compared to control (3.16 +/- 1.45 vs 4.61 +/- 1.47). The analysis of recovered populations of total colifom, E. coli and total culturable anaerobes indicates that these bacteria were not affected (P < 0.05) by this compound. In addition, there was no alteration (P < 0.05) in concentrations of acetate, propionate, and butyrate in the cecum or rectum of pigs among all groups. No adverse biological effect of SNE administration was observed. These results implicate that SNE may have the potential to be developed as an intervention to control Salmonella in pigs.

Last Modified: 10/25/2014