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United States Department of Agriculture

Agricultural Research Service

Title: Delivery of a Fatty Acid and Benzalkonium Chloride Topical Antimicrobials from a Starch-Oil Composite Dispersion

Authors
item Wille, J - NON-USDA
item Babad, J - NON-USDA
item Fanta, George
item Cope, F. - NON-USDA

Submitted to: Controlled Release Society
Publication Type: Proceedings
Publication Acceptance Date: January 1, 2001
Publication Date: June 1, 2001
Citation: WILLE, J., BABAD, J., FANTA, G.F., COPE, F. DELIVERY OF A FATTY ACID AND BENZALKONIUM CHLORIDE TOPICAL ANTIMICROBIALS FROM A STARCH-OIL COMPOSITE DISPERSION. CONTROLLED RELEASE SOCIETY. 2001. v. 28. p. 5-6.

Technical Abstract: Palmitoleic acid(PA) was incorporated into a starch-petrolatum dispersion (Derm-Care(TM) Lotion). Microbiological studies showed that less than 20 minutes contact (0.5mg/cm2 of PA) was sufficient to kill more than 50 times each of Staphylococcus aureus and a methacillin-resistant strain of S. aureus, but was ineffective against gram-negative bacteria. By contrast, incorporation of benzalkonium chloride(BC) into Derm-care(TM) lotion was effective in killing both gram-positive and gram-negative bacteria.

Last Modified: 12/19/2014