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United States Department of Agriculture

Agricultural Research Service

Title: Impact of Thermal Environment and Spray-Dried Plasma on the Acute Phase Response of Pigs Challenged with Lipopolysaccharide (Lps)

Authors
item Frank, J - UNIV OF MISSOURI
item Carroll, Jeffery
item Allee, G - UNIV OF MISSOURI
item Zannelli, M - SIMPLE SOLUTIONS

Submitted to: Journal of Animal Science Supplement
Publication Type: Abstract Only
Publication Acceptance Date: October 30, 2002
Publication Date: March 17, 2003
Citation: FRANK, J.W., CARROLL, J.A., ALLEE, G.L., ZANNELLI, M.E. IMPACT OF THERMAL ENVIRONMENT AND SPRAY-DRIED PLASMA ON THE ACUTE PHASE RESPONSE OF PIGS CHALLENGED WITH LIPOPOLYSACCHARIDE (LPS). JOURNAL OF ANIMAL SCIENCE SUPPLEMENT. 2003. v. 81(Suppl.2):Abstract p. 63.

Technical Abstract: Forty barrows (TR4 x C22) were weaned at 17 d of age (6.27 +/- 0.30 kg) and housed 2 pigs/pen in a thermal neutral environment (TN: constant 26.7 C) and fed diets with or without 7% spray-dried plasma (SDP). On d 7, one pig/pen was moved into a cold environment (CE: constant 15.6 C). Pigs were fitted with jugular catheters on d 11. The following day, 16 pigs/environment (8 pigs/dietary treatment) were challenged with 75 g/kg of BW of LPS. Blood samples were collected over a 4.5-h period, then pigs were sacrificed for tissue sample collection. Pigs housed in the CE consumed more feed and had lower gain to feed ratios than pigs housed in TN from d 7 to 11 (P < 0.001). There were no environment by diet interactions from d 7 to 11 (P > 0.78). Basal serum ACTH and cortisol (CS) were lower in TN pigs compared to CE pigs (P < 0.001). Pigs fed diets without SDP had lower serum CS over the 4.5-h period compared to pigs fed SDP (time x diet, P < 0.001). Serum tumor necrosis factor-alpha were highest for pigs consuming SDP in the CE, while there were no differences among the other treatments (time x diet x environment, P < 0.02). Pigs housed in the CE had higher serum interleukin-1beta (IL-1) and interleukin-6 (IL-6) compared to TN pigs (P < 0.001). Furthermore, pigs consuming SDP also had slightly higher serum IL-1 (P < 0.10) and significantly higher IL-6 compared to the pigs fed no SDP. Overall, there were no consistent interactions between feeding SDP and thermal environment. Pigs consuming diets containing SDP and subsequently challenged with LPS responded with elevated serum concentrations of CS and cytokines when compared to pigs fed diets with no SDP. Housing pigs in a CE increased the basal ACTH and CS, and when challenged with LPS, resulted in elevated serum cytokines. Pigs consuming SDP and exposed to an endotoxin challenge that circumvents mucosal immune protection become immunologically hyper-responsive.

Last Modified: 8/21/2014
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