Skip to main content
ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #139010
Title: MUSCLE PROTEIN SYNTHESIS IS MODERATELY REDUCED IN EARLY NEONATAL ENDOTOXMIA

Author
item ORELLANA, RENAN - BAYLOR COLLEGE OF MED
item O'CONNOR, PAMELA - BAYLOR COLLEGE OF MED
item NGUYEN, HANH - BAYLOR COLLEGE OF MED
item BUSH, JILL - BAYLOR COLLEGE OF MED
item THIVIERGE, CAROLE - BAYLOR COLLEGE OF MED
item SURYAWAN, AGUS - BAYLOR COLLEGE OF MED
item FIOROTTO, MARTA - BAYLOR COLLEGE OF MED
item Davis, Teresa

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 4/20/2002
Publication Date: 4/20/2002
Citation: Orellana, R.A., O'Connor, P.M.J., Nguyen, H.V., Bush, J.A., Thivierge, C., Suryawan, A., Fiorotto, M.L., Davis, T.A. 2002. Muscle protein synthesis is moderately reduced in early neonatal endotoxemia [abstract]. Federation of American Societies for Experimental Biology Conference. 16(4):A235-A236.

Interpretive Summary: Not Necessary for an Abstract

Technical Abstract: Muscle protein synthesis is reduced as much as 50% after a septic challenge in adults. To determine the effect of sepsis on muscle protein synthesis in neonates, a highly anabolic population with high rates of muscle protein synthesis, 7-d-old pigs (n=10/group) were infused with Endotoxin (LPS,0 and 10 micro g/kg/hr for 8 hr) while amino acids and glucose were kept at fed levels by dextrose and amino acid infusions. LPS increased temperature, heart rate, and plasma TNF-alpha, IL-1, cortisol, and lactate, indicating a septic-like state. LPS increased blood insulin and decreased glucose and amino acids suggesting a lack of insulin resistance. LPS decreased protein synthesis in longissimus dorsi (-11%) and gastrocnemius (-15%) muscles but not in masseter and cardiac muscles. In contrast, LPS increased protein synthesis in liver (22%), spleen (28%), kidney (53%), lung (50%), jejunum (19%), diaphragm (21%) and skin (13%), but not in stomach, pancreas, or brain. These findings suggest that muscle protein synthesis in neonatal pigs is relatively resistant to the catabolic effects of early endotoxemia when substrate supply is maintained.