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United States Department of Agriculture

Agricultural Research Service

Title: Molecular and Biological Characterization of Naturally Occurring Recombinant Avian Leukosis (Alv) Isolated from Egg-Type Chickens Suffering from Myeloid Leukosis

item Lupiani, Blanca - MICH STATE UNIV
item Pandiri, Arun - MICH STATE UNIV
item Hunt, Henry
item Reed, Willie - MICH STATE UNIV
item Fadly, Aly

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: July 13, 2002
Publication Date: N/A

Technical Abstract: A case of myeloid leukosis has recently been reported in commercial layers. Molecular characterization of viruses isolated from affected chickens proved that they are recombinant viruses with subgroup B avian leukosis virus (ALV) envelope and subgroup J ALV LTR. The recombinant virus termed ALV-J/Benv replicated in chicken embryo fibroblasts (CEF) that are known to be resistant to ALV-J, but failed to replicate in CEF known to be resistant to subgroup B ALV. Chickens of line 15 X 7 known to be highly susceptible to ALV infection and tumors were inoculated with ALV-J/Benv at hatch; chickens were monitored for ALV infection and tumors for 30 weeks. The tumor incidence in ALV-J/Benv-inoculated chickens was 40% compared with 20% and 76% in chickens inoculated with strain ADOL-Hc1 of ALV-J or RAV-2, a subgroup B ALV, respectively. Results suggest that natural recombination among various subgroups of ALV may influence their ability to induce tumors.

Last Modified: 4/20/2015
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