ARS | Publication request: SELENIUM FROM BROCCOLI: A UNIQUE ANTI-CANCER AGENT?

Submitted to: Leatherhead Food Research Association Food Industry
Publication Type: Review Article
Publication Acceptance Date: April 8, 2002
Publication Date: N/A

Technical Abstract: A recent placebo-controlled study has demonstrated that supplemental intakes of selenium (Se), an essential nutrient, may reduce the incidence and mortality of several important cancers. Selenium is found as a component of many molecules including amino acids, methylated compounds and inorganic salts. The chemical form of Se determines the metabolic route of the molecule, and consequently, the potential health benefits. The chemical form of Se, as well as the total Se content of a food, varies. Broccoli, which contains Se in a unique organic form, has the ability to accumulate high concentrations of Se. Selenium from high-Se broccoli does not accumulate in the tissues and organs of humans and rats as well as other forms of Se. However, animal studies have demonstrated that Se from high-Se broccoli is more effective than other forms of Se for the prevention of chemically- induced colon and mammary cancers.