|Hambach, A - UNIVERSITY OF MISSOURI|
|Fangman, T - UNIVERSITY OF MISSOURI|
Submitted to: American Association of Swine Veterinarians Annual Meeting
Publication Type: Abstract Only
Publication Acceptance Date: March 2, 2002
Publication Date: N/A
Technical Abstract: Our objective was to determine if changes occurred in serum C-reactive protein (CRP), haptoglobin (HG), cortisol (CS) and TNF-alpha, and rectal temperature (RT) in response to an acute enterotoxemia elicited by anti- biotic treatment (AT). Twelve pigs were non-surgically cannulated 1 d prior to blood collection. Rectal temperature was monitored on 12 non-cannulated pigs. All pigs received 2.4 X 10**8 colony-forming units of E. coli K88 orally. At 5 h, 6 pigs in each group were injected with 0.5 mL of saline (Group A) and 6 pigs were injected with 25 mg of Ceftiofur HCl (Group B). Blood collection and RT monitoring occurred hourly from -1 h before to 5 h post-E. coli ingestion (PRE). Between 5 and 8 h, blood collection and RT monitoring occurred every 30 min and a final data collection occurred at 24 h (POST). During the PRE period, RT increased (P<0.0001) in both groups. During the POST period, a time X treatment interaction (P<0.02) was observed such that the Group B pigs had the highest RT. At 30 min post-AT, the RT of Group B pigs began to rise and remained elevated for the next 18 h compared to the Group A pigs. There was a time X treatment interaction (P<0.0001) observed for serum CRP. Serum CRP in Group B increased 30 min post-AT. A time effect (P=0.01) was observed in the PRE period due to an initial drop in serum HG and then a slight rise prior to the POST period. During the POST period, there was an increase (P<0.0001) in serum HG, with the highest levels observed at 24 h POST. Serum CS increased (P<0.0001) for both groups during the PRE period. During the POST period, a time X treatment interaction (P=0.05) was observed such that serum CS was higher in the Group B pigs. Serum TNF-alpha was virtually undetectable throughout the entire blood collection period.