ARS | Publication request: DUAL INFECTION OF TURKEYS WITH NEWCASTLE DISEASE VIRUS AND AVIAN PNEUMOVIRUS COLORADO REPLICATES CLINICAL SIGNS REPORTED IN THE FIELD

Submitted to: Symposium on Avian Pneumovirus
Publication Type: Abstract Only
Publication Acceptance Date: September 24, 2001
Publication Date: September 24, 2001

Technical Abstract: Descriptions of experimental APV infections are typically less severe than those seen in field cases. Previous studies of APV and E. coli suggest this discrepancy is due to secondary agents. Field observations indicate APV infections are more severe with concurrent infection by Newcastle disease virus (NDV). The current study examined the role of lentogenic NDV Vin the APV disease process. Two-week-old commercial turkey poults were infected with APV/CO. Three days later these poults received an additional inoculation of either NDV or E. coli. Dual infection with APV and NDV or E. coli resulted in increased morbidity rates with poults receiving APV/NDV having the highest morbidity rates and consistent lesions of infraorbital sinuses, periocular and submandibular swelling. These lesions were not present in the APV, NDV or E. coli groups. These results demonstrate co-infection with APV and NDV will result in clinical signs and lesions similar to those in the field.