Submitted to: Animal Genomics Symposium North Carolina State University Raleigh
Publication Type: Abstract Only
Publication Acceptance Date: August 16, 2001
Publication Date: August 16, 2001
Citation: CHENG, H.H. TAPPING THE CENTRAL DOGMA FOR DISEASE RESISTANCE GENES IN POULTRY. ANIMAL GENOMICS SYMPOSIUM NORTH CAROLINA STATE UNIVERSITY RALEIGH. 2001. NO PAGE NUMBERS. Technical Abstract: Achievements in human and model organism genomics strongly suggest that this field will play an increasingly important role in poultry at both the academic and industrial levels, as they already had done in many plant and other animal species. Currently, a number of groups have identified quantitative trait loci (QTL) for economically important traits in poultry, especially disease resistance. Unfortunately, the QTL are not resolved sufficiently for use either as genetic markers or to clone the causative gene. Thus, alternative strategies need to be implemented to achieve these goals. Regarding resistance to Marek's disease, we are utilizing three complementary approaches that are at the DNA (recombinant congenic strains), RNA (DNA microarrays), and protein (yeast two-hybrid screen) levels. The relative strengths and weaknesses of each approach will be discussed.