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United States Department of Agriculture

Agricultural Research Service

Title: Differential Activation of Signal Transduction Pathways Mediating Phagocytosis, Oxidative Burst, and Degranulation by Chicken Heterophils in Response to Stimulation with Opsonized Salmonella Enteritidis

Authors
item Kogut, Michael
item Genovese, Kenneth
item Lowry, Virginia - TAMU

Submitted to: Congress International Society Develop Comparative Immunology
Publication Type: Abstract Only
Publication Acceptance Date: July 17, 2001
Publication Date: N/A

Technical Abstract: Salmonella arizonae (SA) and S. gallinarum (SG) are pathogenic in young poultry. We have shown that immune lymphokines (ILK), produced by S. enteritidis (SE)-immunized chickens, provide protection against Salmonella infections in day-old poultry. The objective of the present study was to determine the effect of ILK on the incidence of horizontal transmission of SA in turkey poults and of SG in broiler chicks assessed in a seeder/contact model. Seeders were challenged with the appropriate bacterium (SA in turkeys, SG in chicks), and contacts were either untreated or administered ILK. Mortality and organ invasion of contact birds were observed. There were no significant differences in mortality between non-treated and ILK-treated contact poults. In contrast, SG was extremely pathogenic to contact chicks. Non-treated contact chicks had a mortality rate of approximately 68%, whereas significant (P < 0.05) reduction in mortality was demonstrated in the contact chicks treated with ILK (15%). Organ invasion of SA to contact turkey poults and SG to contact broiler chicks was significantly (P < 0.05) decreased by the administration of ILK. Bacterial recovery of SA or SG from the liver/spleen and cecal tonsil from contact poults and chicks, respectively, was dramatically reduced in the ILK-treated birds when compared to the non-treated contacts. These results suggest that prophylactic administration of ILK to young turkeys and chickens significantly reduces the horizontal transmission of Salmonella in poultry. These results also suggest the possibility of using a non- vaccine immunologically-based strategy against Salmonella in poultry.

Last Modified: 9/21/2014
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