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United States Department of Agriculture

Agricultural Research Service

Title: Comparative Positional Candidate Cloning: Kit As a Candidate Gene for the Hereford Coat Colour Phenotype

Authors
item Grosz, Michael
item Fahrenkrug, Scott
item Macneil, Michael

Submitted to: International Symposium Candidate Genes for Animal Health
Publication Type: Proceedings
Publication Acceptance Date: August 1, 1999
Publication Date: October 1, 1999
Citation: GROSZ, M.D., FAHRENKRUG, S.C., MACNEIL, M.D. COMPARATIVE POSITIONAL CANDIDATE CLONING: KIT AS A CANDIDATE GENE FOR THE HEREFORD COAT COLOUR PHENOTYPE. INTERNATIONAL SYMPOSIUM CANDIDATE GENES FOR ANIMAL HEALTH. 1999. v. 42. p. 160-162.

Interpretive Summary: The spotted locus is responsible for several phenotypically distinguishable piedald patterns in cattle, including Hereford, or white face (SH), lineback (SP), and recessive spotting (s), in addition to non-spotted (S+). In a backcross mapping population, the S locus has been mapped by genetic linkage to bovine chromosome 6, showing complete linkage with microsatellite marker CA028. This region corresponds comparatively to a region on mouse chromosome 5 which houses several coat color mutations, among which homology is possible with Hardy- Zuckerman 4 feline sarcoma viral oncogene homology (KIT), Patch (Ph), and Rump white (Rw). Mutations at these loci resemble mutations at the bovine S locus in both phenotype and mode of inheritance. Data are presented which show genetic linkage between the bovine S locus and microsatellite markers on chromosome 6. Candidate genes for the bovine S locus are discussed.

Technical Abstract: The spotted locus is responsible for several phenotypically distinguishable piedald patterns in cattle, including Hereford, or white face (SH), lineback (SP), and recessive spotting (s), in addition to non-spotted (S+). In a backcross mapping population, the S locus has been mapped by genetic linkage to bovine chromosome 6, showing complete linkage with microsatellite marker CA028. This region corresponds comparatively to a region on mouse chromosome 5 which houses several coat color mutations, among which homology is possible with Hardy- Zuckerman 4 feline sarcoma viral oncogene homology (KIT), Patch (Ph), and Rump white (Rw). Mutations at these loci resemble mutations at the bovine S locus in both phenotype and mode of inheritance. Data are presented which show genetic linkage between the bovine S locus and microsatellite markers on chromosome 6. Candidate genes for the bovine S locus are discussed.

Last Modified: 11/27/2014
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