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United States Department of Agriculture

Agricultural Research Service

Title: Epidemiologic Aspects, Control, and Importance of Multiple-Drug Resistant Salmonella Typhimurium Dt104 in the United States

Authors
item Akkina, Judy -
item Hogue, Allan -
item Angulo, F -
item Johnson, R -
item Petersen, K -
item Saini, P -
item Cray, Paula
item Schlosser, W -

Submitted to: Journal of Veterinary Medicine
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: January 15, 1999
Publication Date: March 15, 1999
Citation: Akkina, J.E., Hogue, A.T., Angulo, F.J., Johnson, R., Petersen, K.E., Saini, P.K., Cray, P.J., Schlosser, W.D. 1999. Epidemiologic aspects, control, and importance of multiple-drug resistant salmonella typhimurium dt104 in the united states. Journal of Veterinary Medicine. 214 (6) P. 790-798

Interpretive Summary: Salmonella typhimurium DT104 first emerged in the UK in the 1980's and is associated with an increase in morbidity and mortality in both humans and animals. It has also been isolated in the US and is now recognized globally. It is characterized by resistance to 5 antimicrobials and has a tendency to acquire additional resistance attributes, especially to the newer drugs which are available to treat both humans and animals. This paper describes the clinical characteristics, prevalence, and risk factors in both humans and animals. Additionally, current control factors, current economic impact on human infections, comparison to other pathogens, and research in progress is discussed. Control of DT104 must occur on a global basis and is complex in magnitude. This information provides a basis for design of research which may facilitate the reduction or elimination of this pathogen.

Technical Abstract: Preventing the development and spread of antimicrobial resistance organisms, such as Salmonella enterica serotype Typhimurium definitive type 104 (DT104), and maintaining the effectiveness of antimicrobials is of critical importance to the public and animal health communities. Multi-drug resistant DT104 (mrDT104) is an example of the increasing emergence of antimicrobial resistant pathogens that are causing international concern. Results of molecular studies have documented that resistance genes in mrDT104 are chromosomally encoded. Implications of chromosomally integrated resistance genes and reversal of resistance are not entirely known. Resistant pathogens limit therapeutic options, which may lead to therapeutic failure and, therefore, increased morbidity and mortality. In addition, Salmonella spp, including mrDT104, are an important cause of financial losses for producers and foodborne illness in the consumer population.

Last Modified: 12/22/2014
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