Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: December 10, 1999
Publication Date: March 15, 2000
Citation: Finley, J.W., Davis, C.D., Penland, J.G. 2000. Interactive effects of dietary fat type and manganese concentration in healthy young women [abstract]. Federation of American Societies for Experimental Biology Journal. 14:A297. Technical Abstract: Manganese (Mn) is a trace element that is essential as well as potentially toxic. We hypothesized that the body has developed homoeostatic mechanisms that efficiently control Mn retention over a wide range of intakes and that dietary fat influences Mn bioavailability. Young women (n=11) were fed 1 or 20 mg of Mn/d in diets enriched in cocoa butter (CB) or corn oil (CO). A tracer (Mn**54) was used to estimate Mn absorption and biological half-life. High Mn slightly depressed bone-specific alkaline phosphatase (AP) and platelet volume but greatly depressed Mn**54 biological half-life. Fat type influenced many variables; polyunsaturated fat increased mean corpuscular hemoglobin (MCH), plasma Mg and ionized Mg and Ca. Absorption was increased by CO but biological half-life was greater with CB. A significant interaction between fat and dietary Mn affected VLDL concentration (p=0.041); it was lower with CO (compared to CB) but only when dietary Mn was high (no fat effect with low Mn). These data demonstrate that Mn homeostasis is maintained at low or high dietary intakes of Mn. However, fat type greatly influences many clinical variables, as well as Mn absorption and retention.