|Bender, C - UNIVER. OF OKLAHOMA|
|Rangaswamy, V - UNIVER. OF OKLAHOMA|
Submitted to: Annual Review of Phytopathology
Publication Type: Review Article
Publication Acceptance Date: October 1, 1999
Publication Date: N/A
Interpretive Summary: Polyketides are a huge group of diverse molecules that are synthesized in a characteristic way called polyketide synthesis. The group includes important antibiotics and therapeutic drugs. They can be synthesized by man, but polyketides are also common in nature and are produced by many different microorganisms and plants. Polyketides made by one group of bacteria, the pseudomonads living on or in plants, are important to plant health. Certain polyketides made by plant-pathogenic pseudomonads are toxic to the plant and contribute to plant disease; other polyketides made by biological control pseudomonads are toxic to plant pathogenic fungi, and can actually suppress plant disease. This article describes recent research on polyketides produced by plant-associated pseudomonads.
Technical Abstract: Polyketides constitute a huge family of structurally diverse natural products including antibiotics, chemotherapeutic compounds, and antiparasitics. Most of the research on polyketide synthesis in bacteria has focused on compounds synthesized by Streptomyces or other actinomycetes; however, plant-associated pseudomonads also produce a variety of compounds via the polyketide pathway including the phytotoxin coronatine, the antibiotic mupirocin, and the antifungal compounds pyoluteorin and 2,4- diacetylphloroglucinol. This review focuses on the mode of action, regulation, biosynthesis, and genetics of these four compounds and the potential use of Pseudomonas-derived polyketide synthases in the generation of novel compounds with unique activities.