Technical Abstract: A series of paired house studies were conducted in Puerto Rico, Arkansas, Alabama and Georgia to determine the efficacy of MSC(TM) to eliminate or reduce salmonellae in broiler chickens. Randomly designed chicks were treated twice with MSC(TM). First chicks were sprayed with an MSC solution using a spray vaccination cabinet in the hatchery. Chicks then received MSC in the first drinking water at the growing house. Chicks then received MSC in the first drinking water at the growing house. Chicks were grown in paired houses that were designed, equipped and managed in similar manners. After grow-out chicks were processed in commercial plants according to industry standards. MSC treated carcasses sampled after final washer and before the final chiller had significantly (p=.05) less salmonellae than untreated control birds. Overall, these data confirm a highly significant reduction in the salmonellae found on processed broiler carcasses treated with MSC. The use of MSC may be a useful approach for control of salmonellae in commercial poultry.