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Title: EXTRACTION AND ENRICHMENT OF PESTICIDES FOR ANALYSIS BY USING BINARY SUPERCRITICAL FLUID MIXTURES

Author
item Snyder, Janet
item HOPPER, MARVIN - FDA, LENEXA, KS
item King, Jerry

Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 3/21/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Traditionally the extraction and cleanup of samples for pesticide residues have required extensive sample preparation. When using supercritical fluid extraction on food matrices containing lipid material, supercritical carbon dioxide has the tendency to extract an excessive amount of lipid matter in addition to target analytes. By utilizing binary mixtures of supercritical fluids, we have shown previously that trace levels of pesticides can be isolated with minimal lipid contamination. In this research, we extended our study to incorporate several classes of pesticides ranging from non-polar chlorinated species to more polar types, such as organophosphorus and pesticides. Binary fluid mixtures utilized for extraction cleanup of spiked and incurred residues include carbon dioxide with nitrogen and carbon dioxide trifluoromenthane ioxide. Optimal pressure and temperatures as well as binary fluid composition were determined for various classes of pesticides in terms of average analyte recoveries. This has permitted assessment of the applicability of the binary fluid approach in terms of multiresidue analysis.