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United States Department of Agriculture

Agricultural Research Service

Title: Protection of Chickens by Inactivated Avian Influenza Virus and Recombinant Fowl Pox Vaccines from H5 Highly Pathogenic Avian Influenza in the Face of Genetic Changes in Field Viruses over Multiple Years

Authors
item Swayne, David
item Perdue, Michael
item Beck, Joan
item Suarez, David

Submitted to: International Symposium on Avian Influenza
Publication Type: Abstract Only
Publication Acceptance Date: May 1, 1999
Publication Date: May 1, 1999

Technical Abstract: Traditionally, control of highly pathogenic (HP) avian influenza (AI) has been by stamping-out policies. In the USA, the Animal and Plant Health Inspection Service has adopted a strategy for future control of HPAI that could potentially include vaccine use in a multifaceted emergency eradication program. Our study was conducted to determine if H5 AI vaccine would provide protection against H5 AI viruses isolated over multiple years. The data demonstrates that frequent changing of H5 AI vaccines may not be necessary to provide effective protection against clinical signs and death caused by field viruses. Immunization with these vaccines should decrease AIV shedding from the oropharynx and cloaca of AI virus exposed chickens. However, viruses with less than 90 percent homology at the HA between vaccine and challenge virus may not result in consistent reductions in AI virus shedding from the oropharynx.

Last Modified: 9/22/2014