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Title: Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management

Author
item STANLEY, CHARLES - The Children'S Hospital Of Philadelphia
item ROZANCE, PAUL - University Of Colorado
item THORNTON, PAUL - Cook Children'S Hospital
item DE LEON, DIVA - The Children'S Hospital Of Philadelphia
item HARRIS, DEBORAH - Waikato Hospital
item HAYMOND, MOREY - Children'S Nutrition Research Center (CNRC)
item HUSSAIN, KHALID - Great Ormond Street Hospital For Children
item LEVITSKY, LYNNE - Massachusetts General Hospital
item MURAD, MOHAMMAD - Mayo Clinic
item SIMMONS, REBECCA - The Children'S Hospital Of Philadelphia
item SPERLING, MARK - University Of Pittsburgh Medical Center
item WEINSTEIN, DAVID - University Of Florida
item WHITE, NEIL - Washington University School Of Medicine
item WOLFSDORF, JOSEPH - Boston Children'S Hospital

Submitted to: Journal of Pediatrics
Publication Type: Review Article
Publication Acceptance Date: 2/13/2015
Publication Date: 6/1/2015
Citation: Stanley, C.A., Rozance, P.J., Thornton, P.S., De Leon, D.D., Harris, D., Haymond, M.W., Hussain, K., Levitsky, L.L., Murad, M.H., Simmons, R.A., Sperling, M.A., Weinstein, D.A., White, N.H., Wolfsdorf, J.I. 2015. Re-evaluating "transitional neonatal hypoglycemia": Mechanism and implications for management. Journal of Pediatrics. 166(6):1520-1525.

Interpretive Summary:

Technical Abstract: A Committee of the Pediatric Endocrine Society was recently formed to develop guidelines for evaluation and management of hypoglycemia in neonates, infants, and children. To aid in formulating recommendations for neonates, in this review, we analyzed available data on the brief period of hypoglycemia, which commonly is observed in normal newborns during the transition from fetal to extrauterine life, hereafter referred to as transitional neonatal hypoglycemia in normal newborns. The goal was to better understand the mechanism underlying this phenomenon in order to formulate recommendations for recognizing neonates requiring diagnosis and treatment during the first days of life for disorders causing severe and persistent hypoglycemia.