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ARS Home » Southeast Area » Gainesville, Florida » Center for Medical, Agricultural and Veterinary Entomology » Mosquito and Fly Research » Research » Publications at this Location » Publication #316594
Research Project: Biting Arthropod Surveillance and Control

Location: Mosquito and Fly Research

Title: Toxicity of Cephalaria species and their individual constituents against Aedes aegypti

Author
item SARIKAHYA, NAZLI - Ege University
item KAYCE, PEYKER - Ege University
item TABANCA, NURHAYAT - University Of Mississippi
item ESTEP, ALDEN - Navy And Marine Corps Public Health Center (NMCPHC)
item Becnel, James
item KHAN, IKHLAS - University Of Mississippi
item KIRMIZIGUL, SUHEYLA - Ege University

Submitted to: Natural Product Communications
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/11/2015
Publication Date: N/A
Citation: N/A

Interpretive Summary: Natural plant derivatives are an important source for new insecticides to control public health pests such as mosquitoes. Cephalaria species are used in folk medicine and the roots of some species are used for their sedative and anti-inflammatory properties. Extracts were collected from 21 species of Cephalaria species from Turkey and were evaluated for their activity against adult and larval Aedes aegypti, the main vector of dengue and yellow fever. Two compounds were identified that showed good activity against larval and adult mosquitoes from a susceptible Ae. aegypti colony as well as a pyrethroid resistant colony. These compounds are a possible source for the development of new insecticides for public health applications.

Technical Abstract: Crude acetone and ethanol extracts of the aerial parts of 21 Cephalaria species collected from Turkey were investigated for larvicidal and adult topical activity against Aedes aegypti. The ethanol extracts from C. elazigensis var. purpurea, C. anatolica, and C. elmaliensis possessed the highest mortality against first instar Ae. aegypti larvae. Luteolin-7-O-ß-D-glycoside (1), isolated from C. elmaliensis ethanol extract, demonstrated 33% and 53% mortality at 0.1 µg/mL concentration against first instar ORL (susceptible) and PR (pyrethroid resistant) strains, respectively. C. scoparia acetone extract showed 100% mortality against adult Ae. aegypti. From this extract compounds 2-8 were isolated. Compound 2 (isoorientin) possessed the highest toxicity with 31.7% and 65% mortality at a 10 µg/mL concentration against adult ORL and PR strains, respectively. This is the first screening report of potential insecticides from Cephalaria species against the yellow fever mosquito, Ae. aegypti, and the active compounds (1 and 2) could lead to the development of a new class of insecticide.