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ARS Home » Midwest Area » Peoria, Illinois » National Center for Agricultural Utilization Research » Renewable Product Technology Research » Research » Publications at this Location » Publication #302209
Title: Enhanced antimicrobial activity of monoglyceride of 7,10-dihydroxy-8(E)-octadecenoic acid

Author
item KIM, H-R - Kyungpook National University
item DASAGRANDHI, C - Kyungpook National University
item SON, H-R - Kyungpook National University
item WANG, F - Kyungpook National University
item Hou, Ching

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 5/7/2014
Publication Date: 5/7/2014
Citation: Kim, H., Dasagrandhi, C., Son, H., Wang, F., Hou, C.T. 2014. Enhanced antimicrobial activity of monoglyceride of 7,10-dihydroxy-8(E)-octadecenoic acid [abstract]. American Oil Chemists' Society. Bio 3.6.

Interpretive Summary:

Technical Abstract: Structural modification of lipids via chemical reaction or microbial bioconversion can change their properties or even create novel functionalities. Enzymatic oxidation of lipids can lead to formation of oxylipin such as hydroxy fatty acids. One of the multi-hydroxy fatty acids, 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) was produced from oleic acid and lipid containing oleic acid by a bacterial Pseudomonas aeruginosa PR3. Recently we have shown that DOD presented strong antimicrobial activity against broad range of pathogenic bacteria. In this study, we tried to enhance the antimicrobial activity of DOD by formation of monoacylglyceride of DOD (DOD-MAG). DOD-MAG was successfully produced with over 80% production yield by lipase-catalyzed esterification under the optimized reaction condition. Antimicrobial activity of DOD-MAG was highly enhanced by ten times compared to that of DOD.