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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #285138
Title: Central insulin and leptin-mediated autonomic control of glucose homeostasis

Author
item MARINO, JOSEPH - University Of Toledo
item XU, YONG - Children'S Nutrition Research Center (CNRC)
item HILL, JENNIFER - University Of Toledo

Submitted to: Cell
Publication Type: Review Article
Publication Acceptance Date: 5/1/2011
Publication Date: 7/1/2011
Citation: Marino, J.S., Xu, Y., Hill, J.W. 2011. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Cell. 22(7):275-285.

Interpretive Summary:

Technical Abstract: Largely as a result of rising obesity rates, the incidence of type 2 diabetes is escalating rapidly. Type 2 diabetes results from multi-organ dysfunctional glucose metabolism. Recent publications have highlighted hypothalamic insulin- and adipokine-sensing as a major determinant of peripheral glucose and insulin responsiveness. The preponderance of evidence indicates that the brain is the master regulator of glucose homeostasis, and that hypothalamic insulin and leptin signaling in particular play a crucial role in the development of insulin resistance. This review discusses the neuronal crosstalk between the hypothalamus, autonomic nervous system, and tissues associated with the pathogenesis of type 2 diabetes, and how hypothalamic insulin and leptin signaling are integral to maintaining normal glucose homeostasis.