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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #234035
Title: SNPs at IL-2 and IL-10 genes are associated with respiratory infection in the elderly and may modulate the effect of vitamin E on lower respiratory infections in elderly women

Author
item BELISLE, SARAH - JM USDA HNRCA @ TUFTS
item HAMER, DAVIDSON - JM USDA HNRCA @ TUFTS/BU
item LEKA, LYNETTE - JM USDA HNRCA @ TUFTS
item Dallal, Gerald
item DELGADO-LISTA, JAVIER - UNIV REINA SOFIA/CIBEROBN
item FINE, BASIL - MT AUBURN HOSPITAL
item Jacques, Paul
item Ordovas, Jose
item Meydani, Simin

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/15/2008
Publication Date: 4/22/2009
Citation: Belisle, S.E., Hamer, D.H., Leka, L.S., Dallal, G., Delgado-Lista, J., Fine, B.C., Jacques, P., Ordovas, J.M., Meydani, S. 2009. SNPs at IL-2 and IL-10 genes are associated with respiratory infection in the elderly and may modulate the effect of vitamin E on lower respiratory infections in elderly women. Journal of Federation of American Societies for Experimental Biology. 23:221.1.

Interpretive Summary:

Technical Abstract: Vitamin E (E) supplementation has been suggested as a preventative measure against respiratory infections (RI) in the elderly. Previously, we showed that E reduced RI in some but not all nursing home residents. The efficacy of E supplementation may depend on individual factors, including specific single nucleotide polymorphisms (SNPs) at immunoregulatory genes. We examined whether an E-gene interaction might explain individual responses to E for protection from RI using data from a previous E intervention study in elderly nursing home residents. The genotype of common SNPs at IL-1beta, IL-2, IL-6, IL-10, TNF-alpha, and IFN-gamma'genes were determined. The effect of E on lower respiratory infections (LRIs) depended on gender and IL-10 -819G>A (P=0.03 for interaction). Further, IL-2 -330A>C (P=0.02 for upper respiratory infection (URI)), IL-10 -819G>A (P=0.08 for URI) and IL-10 -1082C>T (P<0.001 for LRI in men) were associated with RI independent of E. Genetics and gender should be considered in future studies of E and LRI. SNPs at cytokine genes may be linked to individual risk of RI in the elderly. Supported by NIA NIH grant 5R01-AG013975, USDA agreement 58-1950-7-707, and a DSM Nutritional Products, Inc. scholarship. CIBEROBN is an initiative of ISCIII.