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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #222295
Title: Effects of folate and vitamin B12 on cognitive function in adult and elderly

Author
item Rosenberg, Irwin

Submitted to: Food and Nutrition Bulletin
Publication Type: Review Article
Publication Acceptance Date: 1/1/2008
Publication Date: 6/1/2008
Citation: Rosenberg, I. 2008. Effects of folate and vitamin B12 on cognitive function in adult and elderly. Food and Nutrition Bulletin. 29(2):S132-S142.

Interpretive Summary:

Technical Abstract: Age-related neurocognitive disorders, primarily Alzheimer’s disease (AD) and Parkinson’s disease (PD), have a major impact on health and well-being. Separate lines of evidence have suggested that B vitamin status may be associated with risk and progression of AD and PD. This report summarizes the evidence for relationships between B vitamin status and supplementation, and age-related neurocognitive disorders. This systematic review identified almost 7000 potentially relevant citations regarding B vitamins and neurocognitive disorders and function. Of these, we reviewed 83 human studies of B vitamins. Among the human studies, the majority were cross-sectional studies that correlated B vitamin status with either cognitive function or dementia diagnosis. There were relatively few intervention studies, longitudinal dietary intake or B vitamin status correlation studies.