Author
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Ordovas, Jose |
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Submitted to: Current Atherosclerosis Reports
Publication Type: Review Article Publication Acceptance Date: 1/15/2007 Publication Date: 5/1/2007 Citation: Ordovas, J.M. 2007. Genetic Links between Diabetes Mellitus and Coronary Atherosclerosis. Current Atherosclerosis Reports. 9(3):204-210. Interpretive Summary: Technical Abstract: Diabetes mellitus is one of the most common endocrine disorders affecting almost 6% of the world's population and with clear indication that its prevalence continues to increase. The causes of diabetes mellitus are multifactorial and in the general population, both genetic and environmental factors contributing evenly to its development. Several genes have been more or less consistently associated with type 2 diabetes mellitus; however; it is not clear how many of those translate into increased cardiovascular disease risk. Recent evidence suggest that genetic variation at the CALPN10, FABP4, GK, GST, PPARA, and PPARG loci may confer higher CVD risk in T2DM subjects; however, the evidence is scattered and inconclusive and its translation into practical clinical testing will require studies properly designed to examined not only simple genetic associations but, more important, gene-gene-environment interactions. |
