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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #330977
Research Project: Discovery and Development of Natural Products for Pharmaceutical and Agrochemical Applications II

Location: Natural Products Utilization Research

Title: Ermophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp.FT087

Author
item LI, CHUN-SHUN - University Of Hawaii
item DING, YUANQING - University Of Mississippi
item YANG, BAO-JUN - University Of Hawaii
item HOFFMAN, NAOMI - Honolulu Botanical Garden
item YIN, HONG-QUAN - University Of Mississippi
item MAHMUD, TAIFO - Oregon State University
item TURKSON, JAMES - University Of Hawaii
item CAO, SHUGENG - University Of Hawaii

Submitted to: Phytochemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/8/2016
Publication Date: 3/16/2016
Citation: Li, C., Ding, Y., Yang, B., Hoffman, N., Yin, H., Mahmud, T., Turkson, J., Cao, S. 2016. Ermophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp.FT087. Phytochemistry. 126:41-6. doi:doi:10.1016/j.phytochem.2016.03.005.

Interpretive Summary: Seven sesquiterpene derivatives were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The comparison of their CD and optical rotation data with those in the literature was employed to elucidate their absolute configurations. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was found moderately active.

Technical Abstract: Seven sesquiterpene derivatives, including chaetopenoids A–F and dendryphiellin A1, and 6-methyl-(2E,4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A–D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A–C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 lg/mL, respectively.