Skip to main content
ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #307806
Title: Lipoprotein(a) metabolism

Author
item LAMON-FAVA, STEFANIA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item DIFFENDERFER, MARGARET - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MARCOVINA, SANTICA - University Of Washington

Submitted to: Current Opinion in Lipidology
Publication Type: Review Article
Publication Acceptance Date: 3/3/2014
Publication Date: 6/1/2014
Citation: Lamon-Fava, S., Diffenderfer, M., Marcovina, S. 2014. Lipoprotein(a) metabolism. Current Opinion in Lipidology. 25(3):189-193.

Interpretive Summary:

Technical Abstract: Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein. The metabolism of this lipoprotein is still not well understood. It has long been known that the plasma concentration of Lp(a) is highly heritable, with its genetic determinants located in the apo(a) locus and regulating the rate of hepatic apo(a) production. Recent human intervention trials have convincingly established that, in addition to apo(a) production, hepatic apoB100 production plays an important role in Lp(a) levels. While the major site and mode of Lp(a) clearance remain unidentified, a recent cell and animal study points to the involvement of the hepatic scavenger receptor class B type I in the uptake of both the lipid and protein constituents of Lp(a) from plasma. Progress in the understanding of Lp(a) metabolism has the potential to lead to the development of novel and specific treatments for the reduction of Lp(a) levels and the associated risk of cardiovascular disease.