|Menendez, Kimberly -|
|Garcia, Maricarmen -|
|Tablante, Nathaniel -|
Submitted to: Avian Pathology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: December 13, 2013
Publication Date: January 24, 2014
Citation: Menendez, K.R., Garcia, M., Spatz, S.J., Tablante, N.L. 2014. Molecular epidemiology of infectious laryngotracheitis: a review. Avian Pathology. 43(2):108-117. DOI: 10.1080/03079457.2014.886004. Interpretive Summary: The complete nucleotide sequence of falcon herpesvirus type I was determined using next-generation sequencing technologies. The data suggest that falcon id herpesvirus type I is closely related to anatid herpesvirus type I, the causative agent of duck plague. The analysis provides insight to the genes involved in pathogenicity.
Technical Abstract: Falconid herpesvirus type 1 (FHV-1) is the causative agent of falcon inclusion body disease, an acute, highly contagious disease of raptors. The complete nucleotide sequence of the genome of FHV-1 has been determined. The genome is arranged as a D-type genome with large inverted repeats flanking a unique short region and short inverted repeats of only 250 bp flanking a unique long region. The FHV-1 genome contains 131 predicted open reading frames that a greater than 100 codons in length. Phylogenetically, FHV-1 is closely related to Anatid herpesvirus 1 and both represent a phylogenetic unique clade of alphaherpesviruses that are distinct from the Itoviruses (PsHV-1 and GaHV-1) and Mardiviruses (GaHV-2, GaHV-3 and MeHV-1). The determination of the genomic sequence of FHV-1 provides the bases for functional analysis of this unique class of avian alphaherpesviruses.