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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR GENETICS, GENOMICS, AND PHYLOGENETICS OF FOODBORNE ZOONOTIC PARASITES AFFECTING FOOD SAFETY AND PUBLIC HEALTH

Location: Animal Parasitic Diseases

Title: Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis

Authors
item Zhao, Y -
item Liu, M -
item Wang, X -
item Liu, X -
item Yang, Y -
item Zou, H -
item Sun, S -
item Yu, L -
item Rosenthal, Benjamin
item Shi, H -
item Boireau, P -
item Wu, X -

Submitted to: Veterinary Parasitology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: April 28, 2013
Publication Date: May 20, 2013
Citation: Zhao, Y., Liu, M.Y., Wang, X.L., Liu, X.L., Yang, Y., Zou, H.B., Sun, S.M., Yu, L., Rosenthal, B.M., Shi, H.N., Boireau, P., Wu, X.P. 2013. Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis. Veterinary Parasitology. 194:211-216.

Interpretive Summary: Certain parasitic infections have been observed to powerfully regulate immune responses in ways that can be either harmful or helpful. Interestingly, such infections (or products derived from such parasites) can ameliorate autoimmune syndromes, such as can occur in the colon. Here, mice prone to colitis were studied to determine the effect of infection with Trichinella spiralis, and a battery of cytokines were tracked to determine their role in enhancing or reducing the influence that such parasites might have on inflammation. Increased secretion of one cytokine, IL-10, was found to blunt the clinical benefit that could be derived. If pursued further, the biological activities of natural infection might lead to more effective management of zoonotic infection, and might also lead to better clinical management of inflammatory disease in animals and people. This would be of interest to veterinarians, epidemiologists, and clinicians.

Technical Abstract: Infection of mice with Trichinella spiralis redirects the mucosal immune system from a Th1 to a protective Th2 response with a reduction in the severity of trinitrobenzesulfonic acid-induced colonic damage. T. spiralis infection induced IL-10 production in a dose-dependent manner in oxazolone (OXZ)-induced colitis. This phenomenon may be responsible for the lack of efficacy of T. spiralis in the treatment of OXZ-induced colitis. These results indicate that if the source of increased IL-10 production is identified and addressed, T. spiralis may alter the Th2 response.

Last Modified: 8/21/2014
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