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United States Department of Agriculture

Agricultural Research Service

Research Project: DEVELOPMENT OF APPROACHES TO PREVENT AND AMELIORATE DISEASES OF CATFISH

Location: Warmwater Aquaculture Research Unit

Title: Multidose pharmacokineetecs of orally administered florfenicol in channel catfish Ictalurus punctatus

Authors
item Gaunt, Pat -
item Langston, C -
item Gao, D -
item Adams, P -
item Crouch, L -
item Sweeny, D -
item Endris, R -

Submitted to: Journal of Veterinary Pharmacology and Therapeutics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 6, 2012
Publication Date: August 8, 2012
Citation: Gaunt, P.S., Langston, C., Gao, D., Adams, P., Crouch, L., Sweeny, D., Endris, R. 2012. Multidose pharmacokineetecs of orally administered florfenicol in channel catfish Ictalurus punctatus. Journal of Veterinary Pharmacology and Therapeutics. p. 1-5.

Interpretive Summary: The pharmacokinetics of an oral dose of the antibiotic florfenicol after an oral dose in channel catfish was studied. Based on the results, an a oral dose of 10mg/kg of body weight for 10 days should be able to control bacterial pathogens in catfish which had an in vitro inhibitory concentration value of < 2.5µg/mL.

Technical Abstract: Plasma disposition of florfenicol in channel catfish was investigated after an oral dose (10mg/kg for 10 days) administered in freshwater at water temperatures ranging from 24.7 to 25.9°C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half-life (t1/2), the maximum concentration at steady-state (Css(max)), time of Css(max) (Tmax), minimal concentration at steady-state (Css(min)), and Vc/F were 9.0 h, 9.72µg/mL, 8 h, 2.53µg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of < 2.5µg/mL.

Last Modified: 8/27/2014
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