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United States Department of Agriculture

Agricultural Research Service

Research Project: Chemistry of Natural Products for Nutraceutical Use, Pest Management and Crop Development

Location: Natural Products Utilization Research

Title: Chemical and biological diversity of the volatiles of five Artemisia species from far east of Russia

Authors
item Ozek, Gulmira -
item Suleimen, Yerlan -
item Tabanca, Nurhayat -
item Doudkin, Roman -
item Gorovoy, Petr -
item Goger, Faith -
item Wedge, David
item Ali, Abbas -
item Khan, Ikhlas -
item Baser, Kemal H. C. -

Submitted to: Records of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: February 19, 2014
Publication Date: May 1, 2014
Citation: Ozek, G., Suleimen, Y., Tabanca, N., Doudkin, R., Gorovoy, P.G., Goger, F., Wedge, D.E., Ali, A., Khan, I.A., Baser, K. 2014. Chemical and biological diversity of the volatiles of five Artemisia species from far east of Russia. Records of Natural Products. 8(3):242-261.

Interpretive Summary: The purpose of this study was to investigate the chemical composition and biological activity of essential oils from aerial parts from four Artemisia species. Plants were collected in the Far East region of the Russian Federation. Oils were distilled and simultaneously analyzed by analytical chemistry techniques and the specific chemical components identified. Artemisis essential oils were subsequently submitted for antifungal and anti-mosquito evaluations. Artemisia species oils showed biting deterrent effects in Aedes aegypti mosquito and Artemisia gmelinii essential oil. Larval bioassay of A. gmelinii and A. olgensis oils showed higher larvicidal activity against Ae. aegypti mosquito larvae. Antifungal activity was evaluated against the strawberry anthracnose-causing fungal plant pathogens Colletotrichum acutatum, C. fragariae and C. gloeosporioides using direct overlay bioautography assay and all showed non-selective weak antifungal activity. The tested Artemisia oils demonstrated moderate antioxidant activity.

Technical Abstract: Aim of the present study was to investigate the chemical composition and biological activity of essential oils from aerial parts of Artemisia argyi, A. feddei, A. gmelinii, A. manshurica, A. olgensis (Asteraceae). Plants were collected in the Far East region (Primorski Krai) of the Russian Federation. Oils were hydrodistilled and simultaneously analyzed by GC-FID and GC/MS techniques. Main constituents were found as follows in Artemisia oils: selin-11-en-4 alpha-ol (18.0%), 1,8-cineole (14.2.0%), artemisia alcohol (12.9%), borneol (9.7%) in A. argyi; camphor (31.2%), 1,8-cineole (17.6%), alpha-thujone (5.7%) in A. feddei; longiverbenone (12.0%), isopinocamphone (8.9%), 1,8-cineole (6.7%), camphor (5.8%), trans-p-menth-2-en-1-ol (5.3%) in A. gmelinii; germacrene D (11.2%), rosifoliol (10.1%), caryophyllene oxide (6.8%), eudesma-4(15),7-dien-1 beta-ol (5.6%) in A. manshurica; eudesma-4(15),7-dien-1 beta-ol (6.9%), caryophyllene oxide (5.6%), guaia-6,10(14)-dien-4 beta-ol (5.1%) and hexadecanoic acid (5.0%) in A. olgensis. Oils were subsequently submitted for antifungal and anti-mosquito evaluations. Artemisia species oils showed biting deterrent effects in Aedes aegypti and Artemisia gmelinii oil with the most active biting deterrence index values of 0.82 ± 0.1 at 10 microgram/mL. Larval bioassay of A. gmelinii and A. olgensis oils showed higher larvicidal activity against Ae. aegypti larvae with LD50 values of 83.8 (72.6 – 95.7) ppm and 91.0 (73.8 – 114.5) ppm, respectively. Antifungal activity was evaluated against the strawberry anthracnose-causing fungal plant pathogens Colletotrichum acutatum, C. fragariae and C. gloeosporioides using direct overlay bioautography assay and all showed non-selective weak antifungal activity. Antioxidant evaluations of the oils were performed by using Beta-carotene bleaching, Trolox equivalent and DPPH tests. The tested Artemisia oils demonstrated moderate antioxidant activity.

Last Modified: 8/21/2014
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