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United States Department of Agriculture

Agricultural Research Service

Research Project: METABOLIC FATE OF CHEMICAL AND BIOLOGICAL CONTAMINANTS

Location: Animal Metabolism-Agricultural Chemicals Research

Title: Application of kidney inhibition swab tests to evaluate penicillin-G residues in sow tissues and body fluids following intramuscular injection

Authors
item Shelver, Weilin
item Lupton, Sara
item Newman, David -
item Larsen, Steven -
item Smith, David

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: July 2, 2013
Publication Date: August 26, 2013
Citation: Shelver, W.L., Lupton, S.J., Newman, D.J., Larsen, S., Smith, D.J. 2013. Application of kidney inhibition swab tests to evaluate penicillin-G residues in sow tissues and body fluids following intramuscular injection [abstract]. Association of Analytical Communities Annual Meeting & Exposition. Poster No. P-M-048.

Technical Abstract: Kidney inhibition swab (KIS) tests, recently adapted by the US FSIS for antibiotics on-site screening, were employed to evaluate the depletion of penicillin-G residues from kidney, liver, muscle, serum, and urine of sows after intramuscular (IM) penicillin-G procaine administration. Sows (n=130; 227.0 +/- 30.8 kg) were provided daily IM doses of penicillin-G (33,000 U/kg bw; 5x the label dose) for 3 consecutive days using 3 separate administration patterns and six sows per treatment. Sows were slaughtered after 5, 10, 15, 20, 25, 32, or 39 day withdrawal periods. Residues depleted most rapidly from liver and skeletal muscle and the slowest from kidney and urine. Kidney was the most appropriate target tissue for detecting penicillin-G residues in carcasses, with two positive results after a 39-day withdrawal period. These data support a 15-day withdrawal period for penicillin-G treated sows though kidneys may need to be excluded from human consumption.

Last Modified: 8/29/2014
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