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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #291407
Title: Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia

Author
item CESARI, MATTEO - University Of Toulouse
item FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PAHOR, MARCO - University Of Florida
item GOODPASTER, BRET - University Of Pittsburgh
item HELLERSTEIN, MARC - University Of California
item ABELLAN VAN KAN, GABOR - University Of Toulouse
item ANKER, STEFAN - Charite' University Hospital Berlin
item RUTKOVE, SEWARD - Harvard Medical School
item VRIJBLOED, JAN WILLEM - Neurotune Ag
item ISAAC, MARIA - European Medicines Agency
item ROLLAND, YVES - University Of Toulouse
item M'RINI, CHRISTINE - Institut Merieux
item AUBERTIN-LEHEUDRE, MYLENE - University Of Quebec
item CEDARBAUM, JESSE - Cytokinetics, Inc
item ZAMBONI, GIUSEPPE - University Of Verona
item SIEBER, CORNEL - Friedrich-Alexander University
item LAURENT, DIDIER - Novartis Institutes
item EVANS, WILLIAM - Glaxosmithkline
item ROUBENOFF, RONENN - Novartis Institutes
item MORLEY, JOHN - St Louis Veterans Medical Center
item VELLAS, BRUNO - University Of Toulouse

Submitted to: Journal of Cachexia, Sarcopenia and Muscle
Publication Type: Review Article
Publication Acceptance Date: 6/11/2012
Publication Date: 8/30/2012
Citation: Cesari, M., Fielding, R., Pahor, M., Goodpaster, B., Hellerstein, M., Abellan Van Kan, G., Anker, S.D., Rutkove, S., Vrijbloed, J., Isaac, M., Rolland, Y., M'Rini, C., Aubertin-Leheudre, M., Cedarbaum, J.M., Zamboni, G., Sieber, C., Laurent, D., Evans, W.J., Roubenoff, R., Morley, J.E., Vellas, B. 2012. Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. 3(3):181-190.

Interpretive Summary:

Technical Abstract: Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7-8, 2011 in Toulouse (France). The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging-related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age-related modifications of skeletal muscle. Specific recommendations about the assessment of aging skeletal muscle in older people and the optimal methodological design of studies on sarcopenia were also discussed and finalized. Although the study of skeletal muscle decline is still in a very preliminary phase, the potential great benefits derived from a better understanding and treatment of this condition should encourage research on sarcopenia. However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject.