Technical Abstract: The objectives of this study were to determine: 1) effective treatments for controlling medusahead and 2) the appropriate plant materials for revegetating medusahead-invaded rangelands. Initial treatments of prescribed burning immediately followed with applications of the preemergent herbicide imazapic (Plateau ®) were applied to three 130 x 165 ft plots at each of five sites in eastern Oregon during the fall of 2010. The same treatment combination was applied to an additional 130 x 165 ft plot at each of the five sites during the fall of 2011. All burned and herbicide treated plots were seeded during the fall of 2011 with either a mix of introduced species, native species, or a combination of introduced and native species. The study also included an untreated reference plot at each of the five sites. Prescribed burning followed with an application of imazapic at a rate of 6 oz/ac substantially reduced medusahead cover and density compared to the untreated reference plots. Fall prescribed burning to remove persistent medusahead litter followed immediately with an application of imazapic at a rate of 6 oz/ac is an effective treatment combination for controlling medusahead and preparing sites for successful revegetation of desirable plants. Initial revegetation success of seeded plants following medusahead control indicated substantially greater establishment of introduced species over native plant materials. Initial results also indicated that reseeding immediately following application of imazapic is not a viable restoration option because of non-target herbicide damage to the seeded vegetation. Instead, our preliminary results suggest initial establishment of seeded plants is best facilitated by using seed mixes predominantly comprised of introduced plant materials and waiting a year after imazapic application before revegetation efforts are attempted.