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United States Department of Agriculture

Agricultural Research Service

Research Project: PHYTOCHEMICALS AND AGING: BIOAVAILABILITY, METABOLOMICS, AND BIOACTIVITY

Location: Human Nutrition Research Center on Aging

Title: Pharmacokinetics of avenanthramides (AV) from AV-enriched malted oats in healthy older adults

Authors
item Mckay, Diane L. -
item Chen, Chung-Yen -
item Collins, William F. -
item Blumberg, Jeffrey B. -

Submitted to: FASEB Letters
Publication Type: Abstract Only
Publication Acceptance Date: March 9, 2011
Publication Date: April 1, 2011
Citation: Mckay, D., Chen, C., Collins, W., Blumberg, J. 2011. Pharmacokinetics of avenanthramides (AV) from AV-enriched malted oats in healthy older adults [abstract]. FASEB Letters. 25:235.

Technical Abstract: Avenanthramides (AV) are a unique group of phytochemicals found in oat bran. In vitro studies show both purified AV and concentrated oat AV mixtures have anti-atherogenic and anti-inflammatory activity, suggesting they may have similar effects in vivo if they are sufficiently bioavailable. The bioavailability of purified AV was previously confirmed in both hamsters and humans. However, their bioavailability from an AV-enriched oat bran product, produced via a proprietary malting technology, was unknown. To determine the bioavailability and pharmacokinetics of AV from AV-enriched oat bran, we conducted a placebo controlled, crossover study in 10 healthy adults, and age 50-70 y with BMI 18.5-29.9. After a 2-d run-in period following a diet absent oats and oat products, subjects consumed either a muffin made with 20 g AV-enriched oat bran (containing 45 mg AV) or a placebo muffin absent oats, with a 1 wk washout period between each intervention. Blood samples were collected at specified time points before and up to 24 h after muffin consumption for determination of 6 AV analogues. Preliminary results following consumption of the AV-enriched oat bran muffin by 6 subjects indicate the maximal plasma concentration (Cmax) and time to reach Cmax (Tmax) of total AV were 32.0 +/- 16.1 ng/mL at 1.9 +/- 0.4 h, respectively, with marked variation between subjects. These data suggest that AV from malted oat bran are bioavailable in healthy older adults. (Supported by USDA and AAFC)

Last Modified: 8/30/2014
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