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United States Department of Agriculture

Agricultural Research Service

Research Project: Chemistry of Natural Products for Nutraceutical Use, Pest Management and Crop Development

Location: Natural Products Utilization Research

Title: Anti-cancer scopes and associated mechanisms of Scutellaria extract and flavonoid wogonin

Authors
item Patel, Paras -
item Joshee, Nirmal -
item Rimando, Agnes
item Parajuli, Prahlad -

Submitted to: Current Cancer Therapy Reviews
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 29, 2012
Publication Date: February 1, 2013
Citation: Patel, P., Joshee, N., Rimando, A.M., Parajuli, P. 2013. Anti-cancer scopes and associated mechanisms of Scutellaria extract and flavonoid wogonin. Current Cancer Therapy Reviews. 9(1):34-42.

Interpretive Summary: Scutellaria plants have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or compounds from Scutellaria known as flavonoids have been scientifically studied for potential anti-cancer activity using cell as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and cancer of the nervous system. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients whose breast cancer has spread. This article is a brief review of pertinent research articles on the anti-tumor efficacy of Scutellaria extracts, particularly those containing the compound wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.

Technical Abstract: Extracts of Scutellaria species have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or flavonoids derived from Scutellaria have been scientifically studied for potential anti-cancer activity using in vitro as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and malignant gliomas. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients with metastatic breast cancer. This article is a succinct review of pertinent research articles on the anti-tumor efficacy and associated molecular mechanisms of Scutellaria extracts, particularly those containing the flavonoid wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.

Last Modified: 7/30/2014
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