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United States Department of Agriculture

Agricultural Research Service

Research Project: USING THE GENOME TO UNDERSTAND IMMUNOGENETICS OF POULTRY

Location: Avian Disease and Oncology Laboratory

Title: Complete genome sequence of an avian leukosis virus isolate associated with hemangioma and myeloid leukosis in egg-type and meat-type chickens

Authors
item Ji, Jun -
item Li, Hongxin -
item Zhang, Huanmin
item Xie, Qingmei -
item Shang, Huiqin -
item Ma, Jingyun -
item Bi, Yingzuo -

Submitted to: Journal of Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 23, 2012
Publication Date: October 1, 2012
Citation: Ji, J., Li, H., Zhang, H., Xie, Q., Shang, H., Ma, J., Bi, Y. 2012. Complete genome sequence of an avian leukosis virus isolate associated with hemangioma and myeloid leukosis in egg-type and meat-type chickens. Journal of Virology. 86(19):10907-10908.

Interpretive Summary: Subgroup J avian leukosis virus (ALV-J) was first isolated from meat-type chickens that developed myeloid leukosis (ML). In recent years, field cases of hemangioma (HE) or HE and ML, rather than ML alone, have been reported in commercial layer flocks exposed to ALV-J with high incidence in China. Here we report the complete genomic sequence of an ALV-J isolate that caused both HE and ML in egg-type and meat-type chickens in China.

Technical Abstract: A new virus isolate was separated from a commercial egg-type flock of chickens in China and was determined as subgroup J avian leukosis virus (ALV-J). ALV-J is known to cause myeloid leukosis. But this new isolate of viruses causes both hemangioma and myeloid leukosis in chickens. Hemangioma is an abnormal buildup of blood vessels in the skin and/or internal organs due to viral infection. The new isolate of ALV-J was completely sequenced and deposited to GenBank. This sequence makes comparative analyses between the new ALV-J isolate and other reported ALV-J isolates possible and provides opportunity for identification of genomic variants that are liable for altering pathogenicity.

Last Modified: 8/27/2014
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