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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCT FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

Location: Natural Products Utilization Research

Title: Exploring the molecular basis of antifungal synergies using genome-wide approaches

Authors
item Agarwal, Ameeta -
item Tripathi, Siddharth -
item Xu, Tao -
item Jacob, Melilssa -
item Li, Xing-Cong -
item Clark, Alice -

Submitted to: Frontiers in Microbiology
Publication Type: Review Article
Publication Acceptance Date: March 12, 2012
Publication Date: March 27, 2012
Citation: Agarwal, A.K., Tripathi, S.K., Xu, T., Jacob, M.R., Li, X., Clark, A.M. 2012. Exploring the molecular basis of antifungal synergies using genome-wide approaches. Frontiers in Microbiology. (3)15:1-6.

Interpretive Summary: This is a review article summarizing genomic profiling strategies for determining the mechanism of action of antifungal synergies, and highlighting the potential applications of these technologies. Given the limitations of currently available antifungal agents and the development of drug resistance, there is an urgent need for discovering new antifungal drugs, in particular drugs that can be used in combination therapies. Identifying the mechanism behind drug synergies is not only an important step towards drug development, but it also has the potential to generate new pharmacological tools for further exploration of the targeted pathways and understanding how they interact with each other.

Technical Abstract: This is a review article summarizing genomic profiling strategies for determining the mechanism of action of antifungal synergies, and highlighting the potential applications of these technologies. Given the limitations of currently available antifungal agents and the development of drug resistance, there is an urgent need for discovering new antifungal drugs, in particular drugs that can be used in combination therapies. Identifying the mechanism behind drug synergies is not only an important step towards drug development, but it also has the potential to generate new pharmacological tools for further exploration of the targeted pathways and understanding how they interact with each other.

Last Modified: 4/17/2014
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