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United States Department of Agriculture

Agricultural Research Service

Research Project: EPIDEMIOLOGY, NUTRITION AND PROBLEMS OF AGING

Location: Human Nutrition Research Center on Aging

Title: Biomarker of whole grain wheat intake associated lower BMI in older adults

Authors
item Ma, Jiantao -
item Ross, Alastair -
item Bruce, Stephen -
item Jacques, Paul -
item Lichtenstein, Alice -
item Saltzman, Edward -
item Booth, Sarah -
item Mckeown, Nicola -

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: March 29, 2012
Publication Date: March 29, 2012
Citation: Ma, J., Ross, A., Bruce, S.J., Jacques, P.F., Lichtenstein, A.H., Saltzman, E., Booth, S., Mckeown, N.M. 2012. Biomarker of whole grain wheat intake associated lower BMI in older adults. Journal of Federation of American Societies for Experimental Biology. 26:808.3.

Technical Abstract: Alkylresorcinols (AR) are phenolic lipids in the bran fraction of some whole grains (wheat, rye and barley). Plasma AR reflect recent intake of these whole grains. We examined the cross-sectional associations between plasma AR (measured by LCMS/ MS), whole wheat intake, and body mass index (BMI) in 407 free-living older adults (166 men and 241 women; 60-81y; mean BMI 27.9 kg/m²). After adjustment for total cholesterol and triglyceride, median plasma AR across quartile categories of AR were 5, 13, 28, and 62 nmol/L, respectively. Whole grain wheat (servings/d) and bran (g/d) intakes were estimated using a semi quantitative FFQ. Spearman correlation coefficients between plasma AR and whole grain wheat and bran were 0.34 and 0.28, respectively. Age and sex adjusted geometric mean daily whole wheat intakes in the lowest and highest quartile categories of plasma AR were 0.4 and 1.1 servings (P-trend <0.0001). Without inclusion of added bran, whole grain intake (g/d) was weakly correlated with plasma AR (r = 0.12, P<0.0001). After adjustment for lifestyle and dietary covariates, mean BMI values in the lowest and highest quartile category of plasma AR were 27.8 and 26.7 kg/m(2), respectively (P-trend 0.03). Our study confirms the observed inverse relationship between whole grain intake and BMI using an independent biomarker of whole grain wheat intake.

Last Modified: 8/22/2014
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