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United States Department of Agriculture

Agricultural Research Service

Research Project: PROTECTIVE ENDOPHYTES OF MAIZE THAT INHIBIT FUNGAL PATHOGENS AND REDUCE MYCOTOXIN CONTAMINATION

Location: Bacterial Foodborne Pathogens & Mycology Research Unit

Title: Interpreting diplodiosis: bioactive metabolites in Stenocarpella maydis ear rot of maize

Authors
item Wicklow, Donald
item Rogers, Kristina -
item Gloer, James -

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: June 7, 2012
Publication Date: June 7, 2012
Citation: Wicklow, D.T., Rogers, K., Gloer, J. 2012. Interpreting diplodiosis: bioactive metabolites in Stenocarpella maydis ear rot of maize. Meeting Abstract.

Technical Abstract: Stenocarpella maydis is a fungal pathogen of major importance that causes a dry-rot of maize ears and is associated with a neuromycotoxicosis in cattle grazing harvested maize fields in southern Africa and Argentina. Chemical investigations of S. maydis rotted kernels at harvest in Illinois led to the detection of diplodiatoxin, chaetoglobosins M, O and K as major components. The limit of detection of these compounds has not been determined, but on the basis of the LC-ESIMS results, these values are expected to be <200 ng for diplodiatoxin and chaetoglobosin K, and between 200 ng and 2 µg for chaetoglobosins M and O. Diplonine, recently isolated by a South African research group from methanol extracts of S. maydis corn cultures, induced neurological signs in guinea pigs resembling some of those occurring in cattle and sheep. This neuromycotoxin was not detected in methanol extracts of S. maydis rotted kernels from Illinois.

Last Modified: 11/20/2014
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