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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #277779
Title: Role and potential mechanisms of anabolic resistance in sarcopenia

Author
item HARAN, PRASHANTH H - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item RIVAS, DONATO A - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item FIELDING, ROGER A - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Journal of Cachexia, Sarcopenia and Muscle
Publication Type: Review Article
Publication Acceptance Date: 4/11/2012
Publication Date: 5/16/2012
Citation: Haran, P., Rivas, D., Fielding, R. 2012. Role and potential mechanisms of anabolic resistance in sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. DOI: 1007/s13539-012-0068-4.

Interpretive Summary:

Technical Abstract: There is a pressing need to understand the aging process to better cope with its associated physical and societal costs. The age-related muscle wasting known as sarcopenia is a major contributor to the problems faced by the elderly. By hindering mobility and reducing strength, it greatly diminishes independence and quality of life. In studying the factors that contribute to the development of sarcopenia, the focus is shifting to the study of disordered muscle anabolism. The abnormal response of muscle to previously well-estabilshed anabolic stimuli is known as anabolic resistance, and may be a key factor in the development and progression of sarcopenia. Factors such as age obesity, inflammation, and lipotoxicity contribute to anabolic resistance, and have been studied either directly or indirectly in cell systems and whole animals. Understanding the physiologic and mechanistic basis of anabolic resistance could be the key to formulating new and targeted interventions that would ease the burden currently borne by the world’s aged population.