Technical Abstract: This study was designed to determine if the present USDA ARS Spray Nozzle models based on water plus non-ionic surfactant spray solutions could be used to estimate spray droplet size data for different spray formulations through use of experimentally determined correction factors or if full spray formulation specific spray nozzle models are required. Twelve spray formulations were evaluated, ten of which contained active product plus additional spray adjuvant, for droplet size across multiple operational points used to define a full spray model response surface. Initial hypothesis of linear responses across the response surfaces for the different spray formulations did not hold preventing the determination of a simple linear correction factor. When compared to water or the water plus non-ionic surfactant, the changes in atomization across the different operational points was not consistent for each formulation with increases and decreases that varied from solution to solution. Attempts to apply regression fits based on solution physical properties were not successful. However, for the active ingredient used, the addition of the different adjuvants tested, with the exception of the polymer, did not significantly change the atomization properties under the high air shear regime. As a result, while there is likely a need to develop multiple atomization models for different formulated active products, the new product specific models could potentially suffice to represent the majority of spray formulation using that specific product across the range of airspeeds tested herein.