Title: One-step production of a biologically active novel furan fatty acid from 7,10-dihydroxy-8(E)-octadecenoic acid Authors
|Ellamar, Joel -|
|Kim, Hak-Ryul -|
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: October 13, 2011
Publication Date: October 13, 2011
Citation: Ellamar, J.B., Hou, C.T., Kim, H. 2011. One-step production of a biologically active novel furan fatty acid from 7,10-dihydroxy-8(E)-octadecenoic acid [abstract]. International Society of Biocatalysis and Agricultural Biotechnology (ISBAB) BIO-3. p. 23. Technical Abstract: Furan fatty acids (F-acids) gain special attentions since they are known to play important roles in biological systems including humans. Specifically F-acids are known to have strong antioxidant activity like radical scavenging activity. Although widely distributed in most biological systems, F-acids are trace components and their biosynthesis is complicated and quite unique to source. Based on biochemical study, they are considered to be an essential nutritional factor for mammals and should be provided through diet. Hence several studies reported chemical synthesis of furan fatty acids using chemical catalysts. However, chemical synthesis requires complicated, multistep operations. In this study we developed a simple one-step synthesis of a novel furan fatty acid 7,10-epoxy-octadeca-7,9-dienoic acid (EODA) from a dihydroxyl fatty acid 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) by heat treatment. Structure of EODA was confirmed by GC/MS, NMR, FTIR analysis and maximum production yield under the reaction conditions of at 90**oC, 24 hour reached 80%.