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Title: Interpretation and use of FRAX in clinical practice - position paper of the International Osteoporosis Foundation and the International Society for Clinical Densitometry

Author
item KANIS, JOHN A. - Non ARS Employee
item HANS, DIDIER - Lausanne University Hospital
item COOPER, CYRUS - University Of Southampton
item BAIM, SANFORD - University Of Miami
item BILEZIKIAN, JOHN P. - Columbia University - New York
item BINKLEY, NEIL - University Of Wisconsin
item CAULEY, JANE A. - University Of Pittsburgh
item COMPSTON, JULIE - Cambridge University
item DAWSON-HUGHES, BESS - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item FULEIHAN, GHADA EL-HAJJ - American University Of Beirut

Submitted to: Osteoporosis International
Publication Type: Review Article
Publication Acceptance Date: 6/7/2011
Publication Date: 7/21/2011
Citation: Kanis, J., Hans, D., Cooper, C., Baim, S., Bilezikian, J., Binkley, N., Cauley, J., Compston, J., Dawson-Hughes, B., Fuleihan, G. 2011. Interpretation and use of FRAX in clinical practice - position paper of the International Osteoporosis Foundation and the International Society for Clinical Densitometry. Osteoporosis International. 22:2395-2411.

Interpretive Summary:

Technical Abstract: The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics, which form the focus of this review. Review of resource documents and joint position statements of ISCD and IOF. Details on the clinical risk factors currently used in FRAX are provided and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available. The wish list of clinicians for the modulation of FRAX is large, but in many instances these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice.