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United States Department of Agriculture

Agricultural Research Service

Research Project: IMPACT OF EARLY DIETARY FACTORS ON CHILD DEVELOPMENT AND HEALTH

Location: Arkansas Children's Nutrition Center

Title: Anti-inflammatory effects of caper (capparis spinosa l.) Fruit aqueous extract and the isolation of main phytochemicals

Authors
item Zhou, Haifeng -
item Jian, Renji -
item Kang, Jie -
item Huang, Xiaoling -
item Li, Yan -
item Zhuang, Changlong -
item Yang, Fang -
item Zhang, Lele -
item Fan, Ziao -
item Wu, Tong -
item Wu, Xianli -

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 12, 2010
Publication Date: December 22, 2010
Citation: Zhou, H., Jian, R., Kang, J., Huang, X., Li, Y., Zhuang, C., Yang, F., Zhang, L., Fan, Z., Wu, T., Wu, X. 2010. Anti-inflammatory effects of caper (capparis spinosa l.) Fruit aqueous extract and the isolation of main phytochemicals. Journal of Agricultural and Food Chemistry. 58(24):12717-12721.

Interpretive Summary: Caper (Capparis spinosa L.) fruits have been used as food as well as folk medicine in the treatment of inflammatory disorders, such as rheumatism. The present study was carried out to study the anti-inflammatory activities of caper fruit aqueous extract and to isolate main phytochemicals from its bioactive fractions. Systematic fractionation and isolation led to the identification of 13 compounds. To our knowledge, 8 of these 13 compounds were identified from caper fruits for the first time. The anti-inflammatory effects of these purified compounds are currently under investigation.

Technical Abstract: Caper (Capparis spinosa L.) fruits have been used as food as well as folk medicine in the treatment of inflammatory disorders, such as rheumatism. The present study was carried out to study the anti-inflammatory activities of C. spinosa L. fruit (CSF) aqueous extract and to isolate main phytochemicals from its bioactive fractions. The CSF aqueous extract were separated into three fractions (CSF1-CSF3) by macroporous adsorption resins. The fractions CSF2 and CSF3 effectively inhibited the carrageenan-induced paw edema in mice. Systematic fractionation and isolation from CSF2t3 led to the identification of 13 compounds (1-13). Their chemical structures were elucidated by spectroscopic analyses including nuclear magnetic resonance (NMR) and mass spectrometry (MS) and literature comparisons. Major compounds found in the bioactive fraction CSF2t3 are flavonoids, indoles, and phenolic acids. To our knowledge, 8 of these 13 compounds (1-4, 6-7, 10, and 13) were identified from caper fruits for the first time. The anti-inflammatory effects of these purified compounds are currently under investigation.

Last Modified: 9/29/2014
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