Technical Abstract: The 4R nutrient stewardship concept was introduced in 2009 by International Plant Nutrition Institute to define the right source, rate, time, and place to apply fertilizers to produce not only the most economical outcome in any given crop but to also to provide desirable social and environmental benefits essential to sustainable agriculture. Fertilizer placement decisions depend on mobility of applied nutrients in the soil and the depth and distribution of the crop’s root system. Various methods are used to apply fertilizers to horticultural crops, including broadcasting, banding, fertigation, foliar application, and micro-injection. Generally, the most appropriate method for any crop increases productivity and profitability and improves fertilizer use efficiency but varies depending on the nutrient element, fertilizer source, soil characteristics, cultural practices, stage of crop development, weather conditions, and farming enterprise constraints. Comparisons among application methods are available for many crops and provide useful information for improving fertilizer placement practices, but many practical questions such as how fertilizer source and availability are affected by irrigation interactions or whether there are ways to manage crop roots for more effective nutrient uptake still remain.