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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR, CELLULAR, AND REGULATORY ASPECTS OF OBESITY DEVELOPMENT IN CHILDREN

Location: Children's Nutrition Research Center

Title: Child health developmental plasticity, and epigenetic programming

Authors
item Zeev, Hochbert -
item Feil, Robert -
item Constancia, Miguel -
item Frage, Mario -
item Junien, Claudine -
item Carel, J-C -
item Boileau, Pascal -
item Le Bouc, Yves -
item Deal, Cl -
item Lillycrop, Karen -
item Scharfmann, Robert -
item Sheppard, Albert -
item Skinner, Michael -
item Szyf, Moshe -
item Waterland, Robert -
item Waxman, David -
item Whitelaw, Emma -
item Ong, Kenneth -
item Albertsson-Wikland, Kerstin -

Submitted to: Endocrine Reviews
Publication Type: Review Article
Publication Acceptance Date: August 27, 2010
Publication Date: April 1, 2011
Citation: Zeev, H., Feil, R., Constancia, M., Frage, M., Junien, C., Carel, J., Boileau, P., Le Bouc, Y., Deal, C., Lillycrop, K., Scharfmann, R., Sheppard, A., Skinner, M., Szyf, M., Waterland, R.A., Waxman, D.J., Whitelaw, E., Ong, K., Albertsson-Wikland, K. 2011. Child health developmental plasticity, and epigenetic programming. Endocrine Reviews. 32(2):159-224.

Technical Abstract: Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.

Last Modified: 8/22/2014
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