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United States Department of Agriculture

Agricultural Research Service

Research Project: INNOVATIVE MATERIALS FOR USE IN MYCOTOXIN DETECTION

Location: Bacterial Foodborne Pathogens & Mycology Research Unit

Title: Physicochemical study on interactions between T-2 and HT-2 toxin derivatives and cyclodextrins

Authors
item Ventrella, Andrea -
item Longobardi, Francesco -
item Agostiano, Angela -
item Pascale, Michelangelo -
item Lippolis, Vincenzo -
item Maragos, Chris
item Catucci, Lucia -

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: November 4, 2011
Publication Date: November 4, 2011
Citation: Ventrella, A., Longobardi, F., Agostiano, A., Pascale, M., Lippolis, V., Maragos, C.M., Catucci, L. 2011. Physicochemical study on interactions between T-2 and HT-2 toxin derivatives and cyclodextrins. II European Conference on Cyclodextrins.

Technical Abstract: Physicochemical interactions occurring between fluorescent anthracene derivatives of T-2 and HT-2 toxins and different cyclodextrins (CDs) were investigated in aqueous solutions by means of UV-Vis absorption, fluorescence emission, and Dynamic Light Scattering. Binding constant values and physicochemical parameters were determined showing '-CDs to give the strongest inclusion reactions with both T-2 and HT-2 derivatives. Such interactions were found to be fundamentally enthalpy driven. Among '-CDs, dimethyl-'-CD (DIMEB) was found to induce the greatest fluorescence intensity enhancement. The findings of this work could be of great interest to improve mycotoxin detection by spectroscopic techniques

Last Modified: 7/22/2014