Technical Abstract: Reproductive performance is the single most important economic animal trait to the livestock industry and is reported to be 5 and 10 times more significant than carcass quality and growth traits respectively. Poisonous plants impact livestock reproductive function in a major way and have been shown to interfere with oogenesis, spermatogenesis, fertilization, placentation, embryo/fetal growth and survival, fetal development (birth defects), postpartum intervals, and neonatal survival. In this review, poisonous plants that interfere with reproductive function are discussed and 9 management tools are recommended to assist livestock producers, veterinarians and extension personnel in management decisions that will reduce losses. This contribution to the text, “Reproductive and Developmental Toxicology”, is also an important resource for students, teachers, land managers, scientists and the general public having an interest in reproductive processes and the negative impact that poisonous plants may have.